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The expression of GRP78, CHOP, and caspase-12 increased significantly in the LPS group compared to the control group (P<0.05).
RT-PCR was performed to validate the expression pattern of selected genes (VDR, GRP78, CHOP, and ATF4) using SYBR Premix EX Taq II.
studied the significance of functional GRP78 gene variants in predicting the onset of type 2 DPN in the Chinese population.
Treadmill exercise can improve cardiac function and reduce cardiac infarction by attenuating the expression of GRP78, DERLIN1, p-PERK, p-eIF2a, ATF4/6, XBP1, CHOP, and cleaved caspase-3 [11, 87].
The results showed that DNJ decreased expression of ER stress markers (e.g., 78 kDa glucose-regulated protein, GRP78; CHOP; and phospho-eIF2) and apoptosis responsive markers (e.g., caspase-3 and caspase-12) in a dose-dependent manner.
Regular exposure to the intermittent hypoxic environment can cause dilation and distortion of ER in the hippocampus of mice that is accompanied by excessive expression of Grp78 , caspase-12, and CHOP; caspase-12 and CHOP are the two mediators associated with ER-induced apoptosis [33, 34].
Schmidt demonstrated that mutant A-1-AT ZZ forms interact with the Grp78, Grp94, and Grp170 chaperones, calnexin, and UGGT .
Shinde et al., "Theloss of glucose- regulated protein 78 (GRP78) during normal aging or from siRNA knockdown augments human alpha-synuclein ([alpha]-syn) toxicity to rat nigral neurons," Neurobiology of Aging, vol.
Inducing apoptosis of cancer cells using small-molecule plant compounds that bind to GRP78. Br.
GRP78 was also significantly lower in the pBOO animals treated with MSC compared to untreated pBOO after 14 days (0.83 [+ or -] 0.12 vs.
Nicotine increases oxidative stress activates NF- kB and GRP78, induces apoptosis and sensitizes cells to genotoxic/xenobiotic stressses by a multiple stress inducer, deoxycholate relevance to colon carcinogenesis.
Based on these findings, the two proteins were designated glucose-regulated proteins (GRP78 and GRP94) in 1977, as their expression levels are regulated by glucose in medium.
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- Groznenskii Rabochii
- Groznyi Sheep
- GRP MOD
- GRP1-Associated Scaffold Protein