La quinasa glucogeno sintetasa-3 (GSK3
) es una proteina serina/treonina quinasa que esta implicada en multiples procesos celulares, su inhibicion permite la sintesis del glicogeno, proteinas y activacion de factores de transcripcion implicados en supervivencia celular (8).
isn't inactivated it causes DNA damage in T cells that are expanding, causing the cells to not survive or function correctly.
Determination of Cytokine and GSK3
Enzyme Gene Expression.
takes centre stage more than 20 years after its discovery, " Biochemical Journal, vol.
Taken together, the reported findings indicate that low-dose TNF-induced absolute tolerance is predominantly controlled via transcriptional mechanisms, that is, C/EBP[beta]-dependent suppression of p65 phosphorylation and potential GSK3
activity (Figure 2).
Numerous studies show that GSK3
action supports cancer cells and suggest that its inhibition may have therapeutic benefits.
Jope, "The paradoxical pro- and anti-apoptotic actions of GSK3
in the intrinsic and extrinsic apoptosis signaling pathways," Progress in Neurobiology, vol.
AS160: Akt substrate 160 kDa; GSK3
: glycogen synthase kinase type 3; IRS: insulin receptor substrate; MAPK: mitogen-activated protein kinase; mTORC2: mechanistic target of rapamycin; PI-3K: phosphatidylinositol-3-kinase; PDK-1: phosphoinositide-dependent kinase; S6K: ribosomal protein S6 kinase.
Antibodies against Akt (pAkt), GLUT4, glycogen synthase kinase-3[beta] (GSK3
), forkhead box protein O (FOXO), and GAPDH were purchased from Santa Cruz Biotechnology (Dallas, TX).
GSK3[alpha] is also able to regulate [beta]-catenin phosphorylation in vitro and in vivo, which indicates that both isoforms of GSK3
contribute to maintain low levels of [beta]-catenin in basal conditions 4].
Wolkenhauer, "Analysing the impact of nucleo-cytoplasmic shuttling of [beta]-catenin and its antagonists APC, Axin and GSK3
on Wnt/[beta]-catenin signalling," Cell Signal, vol.
The drug locks onto the GSK3
protein, which plays a causative role in insulin resistance and Type II diabetes, rendering it harmless and unable to wreak havoc inside the body.