"There is mounting evidence that the GST superfamily of genes, including three major classes, GSTM1, GSTT1
and GSTP1, are associated with various diseases, including cancers, asthma, atherosclerosis, allergies, Alzheimer's and Parkinson's disease.
 showed the concentration of Hg-B for genotype GSTT1
+ was negatively correlated with GSTM1+ among a group of students from Austrian population.
Whole blood samples processed with standard phenol chloroform protocol for DNA isolation were genotyped using multiplex PCR approach for simultaneous identification of GSTM1 and GSTT1
Corraa et al., "Avaliacao da influancia da nulidade dos genotipos GSTT1
e GSTM1 na carcinoganese em cabeca e pescoco," Revista da Associacao Medica Brasileira, vol.
Woitowitz, "GSTM1, GSTT1
, and GSTP1 polymorphism and lung cancer risk in relation to tobacco smoking," Cancer Letters, vol.
The association of GSTM1 and GSTT1
polymorphisms with squamous cell carcinoma of cervix in Pakistan.
A recent meta-analysis conducted in 2012 showed that GSTM1 and GSTT1
null polymorphisms were associated with a significantly increased risk of male infertility, whereas the GSTP1 Ile105Val polymorphism has a protective effect against the development of male infertility.[sup] For GSTP1 Ile105Val polymorphism, however, there were some limitations in this meta-analysis.
The glutathione S-transferases (GSTM1, GSTT1
, etc) are one family of enzymes responsible for the detoxification process, particularly mercury and other toxic metal compounds.
The glutathione-s-transferase gene polymorphisms (Gstt1
, Gstm1, and Gstp1) in patients with non-allergic nasal polyposis.
Results of other studies investigating the associations of GSTM1 and GSTT1
polymorphisms with T1DM suggest that the GST M1 null genotype is associated with T1DM protection and T1DM age-at-onset and that susceptibility to T1DM may involve GST conjugation (6).
Pathology Genes Orofacial clefts CL/P BMP4 CRISPLD2 FGF8 FGFR1 FGFR2 FOXE1 GLI2 GSTM1 GSTT1
JAG2 LHX8 MSX1 MSX1 MSX2 NAT1 NAT2 PTCH PVRL1 RYK SATB2 SKI SPRY2 TBX10 TGFB3 ATM Papillary thyroid cancer NKX2 RET (RET/PTC rearrangement) DFNB31 Hypothyroidism PTPN22 SH2B3 VAV3
Oxidative stress is controlled by glutathione (GSH), glutathione S-transferase (GST), Glutathione S-Transferase Theta 1 (GSTT1
), Bax, and Bcl-2.