GTF2IGeneral Transcription Factor 2-i
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A specific missense mutation in GTF2I occurs at high frequency in thymic epithelial tumors.
They compared her genome with that of people who had typical WS and found that she has the GTF2I gene, which most people have, but that other children with WS lack this.
The next step is to find out whether GTF2I, which regulates other genes, helps determine brain function of controls the production of hormones that moderate trust and emphathy.
TFII (GTF2I) was classified as a general transcription factor when it was first identified.
Another gene, GTF2I, which was important in neurodevelopment and neurocognition, was found dynamically regulated from normal to AD stage.