Encouraged in part by our findings on the role of apoE in neurobiology, I proposed to the Gladstone Trustees in the early 1990s that we consider establishing a Gladstone Institute of Neurological Disease
Therapeutic manipulation of repair factors such as BRCA1 may ultimately be used to prevent neuronal damage and cognitive decline in patients with Alzheimer's disease or in people at risk for the disease," says senior author Lennart Mucke, MD, director of the Gladstone Institute of Neurological Disease
Dr Li Gan, of the Gladstone Institute of Neurological Disease
in San Francisco, said it could prove an effective treatment for dementia, which affects 850,000 people in Britain.
Senior Investigator, Gladstone Institute of Cardiovascular Disease and Gladstone Institute of Neurological Disease
, President Emeritus/Founder, Gladstone Institutes, and Professor, Departments of Pathology and Medicine, University of California, San Francisco, California-USA
From both a scientific and clinical perspective, I am thrilled about the consistency of findings obtained in aMCI patients and related animal models," said Lennart Mucke, director of the Gladstone Institute of Neurological Disease
and professor of neurology and neuroscience at the University of California San Francisco.
In the new study, amyloid-beta triggered excessive firing of neurons, leading to subtle seizures in parts of the mouse brain that are central to memory and learning, says study coauthor Lennart Mucke, a neurologist at the Gladstone Institute of Neurological Disease
at the University of California, San Francisco.
Cells have developed a really elegant way to maintain homeostasis and protect themselves from faulty proteins," says senior author Steven Finkbeiner, MD, PhD, a senior investigator at the Gladstone Institute of Neurological Disease
Scientists Anatol Kreitzer, PhD and Karl Deisseroth, MD PhD at the Gladstone Institute of Neurological Disease
(GIND) and Stanford University used genetic methods to allow mice to produce a light-sensitive protein in very select group of cells in the brain.
Scientists from the Gladstone Institute of Neurological Disease
(GIND), UCSF, and Stanford have found that collagen VI may protects brain cells against amyloid-beta (Aa) proteins, which are believed to cause Alzheimer"s disease.