However, higher glucose infusion rates
were required on the first day in the hypophosphatemia group to prevent hypoglycemia of SGA preterm infants.
(2) Glucose infusion rate (GIR) was increased by 2 mg/kg/min every 30 minutes if blood sugar continued to be below 40 mg/dL to a maximum glucose infusion rate of 14 mg/kg/min.
The initial glucose infusion rate (6 [+ or -] 0 mg/kg/min versus 4.8 [+ or -] 1.4 mg/kg/min, P < 0.001), the mean maximum glucose infusion rate (6.7 [+ or -] 1.6 mg/kg/min versus 5.6 [+ or -] 2 mg/kg/min, P = 0.03), the maximum concentration of glucose infused (13.8 [+ or -] 2.9% versus 10.9 [+ or -] 1.9%, P < 0.001), and the median total amount of glucose infused were significantly lower in the intervention group (median, IQR: 6.2 g/kg/day; 5.5 to 7.9 g/kg/day versus 5.1 g/kg/day; 4.2 to 6.2 g/kg/day, P = 0.005).
Compared with the NC group, rats in the HF group showed higher levels of body weight, fasting plasma glucose, fasting serum insulin, LDL-c, and a lower level of glucose infusion rate (Table 2).
With metformin treatment for 4 weeks, the IR of the high-fat diet induced obese rats was obviously improved, manifested as enhanced glucose infusion rate, reduced serum TG and serum insulin levels, and down-regulated mRNA expression of PEPCK, G-6-Pase (Table 2, Figure 1).
TABLE 1: Blood glucose level, glucose infusion rate
(GIR), and endogenous glucose production (EGP) of RO5126766-treated db/db mice in the hyperinsulinemic-euglycemic clamp test.
Fasting endogenous glucose production ([micro]mol x [kg.sup.-1] - [min.sup.-1]) was calculated by dividing the [6, 6- [sup.2][H.sub.2]] glucose infusion rate
([micro] mol x [kg.sup.-1] x [min.sup.-1]) by the steady-state concentration ratio of [6, 6- [sup.2][H.sub.2]] glucose (99% of tracer) divided by tracee plus tracer glucose.
Researchers evaluated the effects of a combination of vitamin C (1000 mg/day) and vitamin E (400 IU/day) on insulin sensitivity in about 40 healthy young men, as measured by glucose infusion rates
(GIR) over a period of four weeks.
Mean steady state plasma glucose values, glucose infusion rates
and insulin values obtained during the study are shown in Fig.
Steady-state plasma glucose infusion rates
during the last 30 minutes of the clamp were used for estimating insulin sensitivity (M-value) [10, 11].
At 20 minutes, glucose levels were significantly higher in the carrageenan-exposed mice (Figure 2(a)), although glucose infusion rates
were identical (Figure 2(b)).
Clamp Glucose Infusion Rates
. The exogenous glucose infusion rates
required to maintain the glucose levels at the clamp point (6-7mmol/L) were higher (P < 0.01) in the D + E group rats than those in the D group rats (144.68 [+ or -] 11.03 versus 114.50 [+ or -] 9.40 [micro]mol/kg/min), while they were still significantly lower (P < 0.01) than those in the C group rats (144.68 [+ or -] 11.03 versus 178.71 [+ or -] 8.73 [micro]mol/kg/min).