Ray, "Glycogen synthase kinase 3
: more than a namesake," British Journal of Pharmacology, vol.
Defize, "Glycogen synthase kinase 3
phosphorylates Jun family members in vitro and negatively regulates their transactivating potential in intact cells," Oncogene, vol.
Eldar-Finkelman, "Glycogen synthase kinase 3
: An emerging therapeutic target," Trends in Molecular Medicine, vol.
(2007) Glycogen synthase kinase 3
: A key regulator of cellular fate.
Inhibition of Glycogen Synthase Kinase 3
Improves Insulin Action and Glucose Metabolism in Human Skeletal Muscle.
Now, Li-Huei Tsai, professor of neuroscience at the MIT, and colleagues have shown for the first time that DISC1 directly inhibits the activity of a brain enzyme called glycogen synthase kinase 3
beta, responsible for schizophrenic conditions.
Researchers believe glycogen synthase kinase 3
(GSK3) could provide a new therapy, paving the way to new treatments.
The study, published in Nature Communications, saw a global research team, led by the University of Bristol study how the activity of the enzyme GSK3 (Glycogen Synthase Kinase 3
) affects the function of podocyte cells, which are crucial in enabling the kidneys to filter blood.
Glycogen synthase kinase 3
(GSK3) was proved to be involved in numerous cellular processes including cell proliferation, apoptosis, and regulation of different cell signalings [16-18].
Dedhar, "Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3
and protein kinase B/AKT by the integrin-linked kinase," Proceedings of the National Academy of Sciences of the United States of America, vol.
It regulates the glucose metabolism by phosphorylating the TBC1D4 protein, also known as AS160, and glycogen synthase kinase 3
Suppression of androgen receptor mediated transactivation and cell growth by the glycogen synthase kinase 3
beta in prostate cells.