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References in periodicals archive ?
The changes in the membrane potential, according to the Goldman-Hodgkin-Katz Equation, are due to the ionic currents that flow as a consequence of a change in the membrane permeability of each ion.
David Goldman (1943) and Hodgkin and Katz (1949) showed that at equilibrium the net flow of all ions through the membrane is zero and the equilibrium potential is determined by the permeability of the membrane to a given ion ([P.sub.j]) according to the following equation known as the Goldman-Hodgkin-Katz Equation:
See Appendix E for the derivation of the Goldman-Hodgkin-Katz Equation.
Notice that when [P.sub.K] [is much greater than] [P.sub.Na] [is greater than] [P.sub.Cl], the Goldman-Hodgkin-Katz Equation reduces to the Nernst Equation for [K.sup.+] (equation 2).
A closer look at the Goldman-Hodgkin-Katz Equation shows that when [P.sub.Na] and [P.sub.Cl] are nonzero, the resting potential will be less than that predicted by the Nernst potential for [K.sup.+].
See Appendix E for a derivation of the Goldman-Hodgkin-Katz Equation.