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(2007) DISC1 regulates neurotrophin-induced axon elongation via interaction with Grb2. J.
As an adapter protein, GRB2 has been identified as a major mediator in Ras-mitogen-activated protein kinase (MAPK) activation, which is essential for growth factor-induced cell proliferation and differentiation and plays a central role in embryo development and malignant transformation.
Campbell, "Adaptor signalling proteins Grb2 and Grb7 are recruited by human G6f, a novel member of the immunoglobulin superfamily encoded in the MHC," Biochemical Journal, vol.
The most well-investigated regulator group are the Sprouty genes, which encode antagonists of FGF signaling by binding with GRB2 thus preventing Ras activation .
The Ras-MAPK pathway is activated by insulin after the binding of Grb2 to phosphorylated IRSs or SH2 domain proteins (Shc and GAB1).
Por otra parte, el gen ATXN2 es activador de GRB2, amplificador de la via de senalizacion del INR (18).
Thus, during HBV infection, the virus can impair the translocation of various components of the TCR (e.g., CD3f, ZAP-70, and Grb2) to lipid rafts; this is a hallmark of defective adaptive immune responses during chronic HBV infection (Barboza 2013; Larkin et al.
Studying mouse embryonic stem cells, they removed Grb2, a protein essential to the ability of the stem cell to transform into other cell types, from the cells.
Despite the complexity of the protein network associated with stem cell development, the team discovered that restoring the interaction between Grb2 and a protein known as Ptpnl 1/Shp2 phosphatase was enough to allow stem cells to again change into other cell types.
Despite the complexity of the protein network associated with stem cell development, the team discovered that restoring the interaction between Grb2 and a protein known as Ptpn 11/Shp2 phosphatase was enough to allow stem cells to again change into other cell types.
Especially, the p96-Dab2 is essential for the development of visceral endoderm during mouse embryogenesis and homologous with 93% full-length of mouse Dab2.5-7 Mechanistically, Dab2 is shown to bind with the growth factor receptor binding protein 2 (Grb2), consequently uncouple the activation of c-Fos expression and Ras/mitogen activated protein kinase (MAPK).8-11
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- Grazing occultation
- grazing on
- grazing pattern
- grazing pattern
- Grazing-Angle X-Ray Diffraction
- Grazing-Emission X-Ray Fluorescence
- Grazing-Exit Particle-Induced X-ray Emission
- grazing-incidence telescope
- Grazingland Animal Nutrition
- Grazinglands Research Laboratory
- Grazzini, Antonio Francesco
- GRB Coordinates Network
- GRB10 adapter protein
- Grb10 adaptor protein
- GRB14 adapter protein
- Grb2 adaptor protein
- GRB7 adapter protein
- Grb7 adaptor protein