H-JEBHerlitz form of junctional epidermolysis bullosa (gene disorder)
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Data were presented on the first three infants with H-JEB treated with topical 0.5% gentamicin twice daily for 2 weeks.
Other molecular changes in the skin, such as increased expression and polarization of beta4 integrin, were consistent with the ability of gentamicin to address the underlying pathophysiology of H-JEB.
By restoring functional laminin 332 in the skin, topical gentamicin appears to address the underlying cause of the bullae associated with H-JEB, but Mr.