HAAH is an excellent target for monoclonal antibody cancer therapeutics, and we have developed several high affinity antibodies against HAAH with good promise as cancer therapeutics," commented K.
This fact, coupled with the exclusivity of the surface expression of HAAH to cancer cells, suggests the potential clinical utility of PAN-622 for the specific delivery of cytotoxic agents to cancer cells.
HAAH over-expression has been detected in primary tumor tissue of all eighteen tumor types tested to date, including cancers of the pancreas, breast, ovary, liver, colon, prostate, lung, brain, and bile duct.
Recent findings in preclinical studies have indicated that over-expression of HAAH is sufficient to induce cellular transformation, to increase cell motility and invasiveness, and to establish tumor formation in animals.
Even partial inhibition of HAAH expression appears to have a beneficial effect on tumor cells, causing them to revert to a more normal phenotype as measured by the inhibition of growth, motility, and invasiveness.
In vitro, Panacea has shown that monoclonal antibodies against HAAH inhibit cell growth in a dose-dependent fashion, inhibit cell motility more than 6-fold and reduce invasion from 26% to 0.
HAAH was discovered by researchers at Brown University (Providence, RI) and the Rhode Island Hospital.
As a part of the agreement, MedImmune made an equity investment in Panacea and agreed to fund research activities related to HAAH
in exchange for an exclusive, worldwide license to therapeutic products directed against HAAH
The abstract described the transfection of neuroblastoma cells with the HAAH gene, and the measurement of their motility using Boyden chamber-type cell culture inserts.
The Company's lead drug candidate, PAN-346, is an antisense-based drug that works at the gene expression level to interrupt and inhibit the process by which HAAH is produced.
Both the preliminary and animal data suggest that HAAH could potentially provide the breakthrough needed in both diagnostic testing and treatment for these and other cancers," said Dr.
We are currently studying the role of HAAH in central nervous system neoplasms and its utility as a target in drug development for brain tumors such as glioblastoma multiforme," said Suzanne de la Monte, M.