We observed a high level (> 1) in all functional areas of HAQDI score for RA patients in both silibinin and placebo groups [Table 4].
Therefore, the ACR recommended the use of disease activity indices that include multiple variables (e.g., DAS28, HAQDI, or SDAI) for the accurate measurement of RA severity and treatment follow-up.
In the third study, also conducted in Europe, the HAQDI improved in both the leflunomide and methotrexate groups.
Abramson, chairman of rheumatology and medicine at the Hospital for Joint Diseases, New York, said he accepted that leflunomide had an effect on the HAQDI on earlier time points, but was not so sure about the 2-year end point.
However, a HAQ score for a disability index (HAQDI
) requires 42 seconds, while a RAPID3 score on the MDHAQ requires 5 seconds.
Among patients receiving 40 mg every other week, mean decreases on the Health Assessment Questionnaire Disability Index (HAQDI
) were 12.9 for physical function, 20.2 for bodily pain, 16.1 for vitality, and 10.3 for mental health.
These improvements were sustained until week 12, by which time significant improvement from baseline was observed for all doses of tofacitinib as compared to the placebo in these categories as well as in HAQDI
score, patient and physician global assessment, swollen joint counts, and pain.