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Related to HB-EGF: Hgf, FGF
HB-EGFHeparin-binding epidermal growth factor-like growth factor
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References in periodicals archive ?
Additionally, the migration of VEGF-A- or FGF7-stimulated endothelial cells depends on EGFR activation via shedding of HB-EGF by aDaM17 [17, 172].
Following a penetrating injury, combinatorial treatments of insulin combined with either heparin binding EGF-like growth factor (HB-EGF; an EGF-related but more potent mitogen [129]) or FGF2 increase proliferation of Muller glia in the zebrafish retina, an effect that is reduced by inhibition of MAPK or JAK/STAT [74, 100, 101].
EGFR activates two major intracellular pathways: (i) the RAS-RAF-MEK-MAPK pathway, which controls gene transcription, cell-cycle progression from the G1 phase to the S phase, and cell proliferation, and (ii) the PI3K-Akt pathway, which activates a cascade of antiapoptotic and prosurvival signals: bFGF, basic fibroblast growth factor, HB-EGF, heparin-binding EGF, MAPK, mitogen-activated protein kinase, PI3K, phosphatidylinositol 3,4,5-kinase, TGFa, transforming growth factor alpha, and VEGF, vascular endothelial growth factor (Figure 1).