HBOCsHemoglobin-Based Oxygen-Carrying Solution
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The laboratory should confirm that interference is caused only by the HBOC and not by hemolysis, since the correction factors for interference from hemolysis will differ from those of HBOCs because of the contribution of intracellular components of red cells (e.g., K, AST, and LDH) [1, 7].
The application of HemogloBind for the removal of Hemolink and other HBOCs would reduce the potential for interference in laboratory methods.
The data support and extend earlier studies investigating the systemic, pulmonary, and microcirculatory effects of HBOCs by identifying that [Hb.sub.p] concentrations greater than 1.1 g/dL may cause systemic and pulmonary vasoconstriction limiting increases in tP[O.sub.2] [14, 36].
Colloids, such as hetastarch, dextran, and HBOCS, are large-molecular substances that remain in the intravascular compartment and expand the intravascular volume.
First-generation HBOCs were developed principally to serve as oxygen carriers and as a substitute for erythrocytes in certain clinical conditions, such as perioperative use (3).
[3] The Afrikaner population group, comprising 12.2% of individuals living in the Gauteng Province of SA, [4] has had three founder BRCA mutations identified to date that result in HBOCS: BRCA1 c.1374delC, BRCA1 c.2641G>T and BRCA2 c.7934delG.
A striking characteristic associated with HBOCs, which circulate in the plasma and have a product-dependent half-life in the range of 8-24 h (7), is the pinkish-red discoloration of serum or plasma samples containing HBOC.
He acknowledges that Jehovah's Witness patients abstain from blood, noting also that many Jehovah Witnesses do accept HBOCs. Professor Mackenzie adds: 'the author is correct, the decision to accept HBOCs is an individual decision.
Hemoglobin-based oxygen carrier (HBOC) [3] solutions have an appearance similar to that of a standard hemolysate, and their presence in patient specimens might be expected to present a problem similar to that of a hemolyzed sample.
HBOCs can be produced from outdated human blood, animal blood, or by recombinant technology.
A significant challenge facing development of HBOCs is their effect on vascular tone as manifested by the hypertension observed in early studies of soluble Hb.
An exception to this has been the development of stabilized hemoglobin-based oxygen carriers (HBOCs).