The laboratory should confirm that interference is caused only by the HBOC
and not by hemolysis, since the correction factors for interference from hemolysis will differ from those of HBOCs
because of the contribution of intracellular components of red cells (e.g., K, AST, and LDH) [1, 7].
The application of HemogloBind for the removal of Hemolink and other HBOCs
would reduce the potential for interference in laboratory methods.
The data support and extend earlier studies investigating the systemic, pulmonary, and microcirculatory effects of HBOCs
by identifying that [Hb.sub.p] concentrations greater than 1.1 g/dL may cause systemic and pulmonary vasoconstriction limiting increases in tP[O.sub.2] [14, 36].
Colloids, such as hetastarch, dextran, and HBOCS
, are large-molecular substances that remain in the intravascular compartment and expand the intravascular volume.
were developed principally to serve as oxygen carriers and as a substitute for erythrocytes in certain clinical conditions, such as perioperative use (3).
 The Afrikaner population group, comprising 12.2% of individuals living in the Gauteng Province of SA,  has had three founder BRCA mutations identified to date that result in HBOCS
: BRCA1 c.1374delC, BRCA1 c.2641G>T and BRCA2 c.7934delG.
A striking characteristic associated with HBOCs
, which circulate in the plasma and have a product-dependent half-life in the range of 8-24 h (7), is the pinkish-red discoloration of serum or plasma samples containing HBOC
He acknowledges that Jehovah's Witness patients abstain from blood, noting also that many Jehovah Witnesses do accept HBOCs
. Professor Mackenzie adds: 'the author is correct, the decision to accept HBOCs
is an individual decision.
Hemoglobin-based oxygen carrier (HBOC
)  solutions have an appearance similar to that of a standard hemolysate, and their presence in patient specimens might be expected to present a problem similar to that of a hemolyzed sample.
can be produced from outdated human blood, animal blood, or by recombinant technology.
A significant challenge facing development of HBOCs
is their effect on vascular tone as manifested by the hypertension observed in early studies of soluble Hb.
An exception to this has been the development of stabilized hemoglobin-based oxygen carriers (HBOCs