HCDR3Heavy Chain Complementarity-Determining Region 3
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In previous experiments, the TSRI team and their collaborators observed that cattle produce antibodies with long HCDR3 loops at a much higher frequency than humans, that these HCDR3 loops are ultra-long, and that bovine immune cells may produce antibodies with effective immunogen binding through a fundamentally different mechanism than takes place in human immune cells.
While no one knows definitively why these powerful antibodies evolved in cattle, one theory holds that the long HCDR3 loops are tied to the animals extensive gastrointestinal systems.