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HCGI episodes were typically brief; they did not differ in duration between the two groups (p=0.23).
Among those guessing that they were using a sham device and also among the group of participants guessing "don't know" the reported rates of HCGI were nearly identical in the two device groups (Table 4).
The rates of illness we observed (as measured by HCGI) were higher than those reported in the earlier work of Payment et al.(1).
Although our definition of HCGI was patterned after the work of Payment et al.
Payment reported an attributable fraction of 35% (of HCGI attributable to drinking water consumption); our study's point estimate of the attributable fraction was 24%.
The experimental group assignment might be revealed to participants through distinguishing features of the intervention (e.g., after installation of the filter, the household water tastes different), through accidental communication of the assignment by study personnel (e.g., the plumber), and, especially in trials with long follow-up, through early or repeated occurrence of an episodic outcome or its symptoms (e.g., HCGI).
For each day in the study period, an HCGI risk curve was applied to historical enterococcus counts at each sampling location to estimate elevated risk associated with bathing at each location.
For the third sensitivity analysis, no bathers were assumed to have been in the water during beach closure days, leading to a level of zero risk of contracting swimming-associated HCGI. The impact of varying this estimate to 10% of bathers in the water despite beach closures was examined in terms of total expected HCGI cases over the study period.
Application of Cabelli's relationship to total number of exposures yielded 95,010 cumulative HCGI cases over the study period (Figure 5A).
Application of Cabelli's relationship resulted in peak attack rates of approximately 600 cases per day in summer months, with the maximum number of HCGI cases at 665.
Figure 6 illustrates that HCGI attack rates are highly influenced by the enterococcus--HCGI risk relationships applied to the exposure data.
Figure 7 shows a comparison of HCGI rates under the clustered and uniform bather distribution scenarios.
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- hCG diet
- hCG-like activity