HCMEC

AcronymDefinition
HCMECHuman Cardiac Microvascular Endothelial Cells
HCMECHuman Cerebral Microvascular Endothelial Cells
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References in periodicals archive ?
At first, the mRNA expressions of COX-2, PGIS, iNOS, eNOS, HIF-1a, HIF-2a, and VEGF in Hx-stimulated HCMEC were detected.
Therefore, based on the Hx-induced expression of COX-2, iNOS, HIF-2a, and VEGF, the effects of TXL were investigated in Hx-stimulated HCMEC.
These data manifested that TXL mainly inhibited the Hx-induced COX-2, iNOS, HIF-2a/VEGF in HCMEC.
Furthermore, the morphological alterations illustrated that Hx brought the conspicuous injury to HCMEC, and TXL could obviously attenuate the pathological alterations with its concentration ascending.
In conclusion, hypoxia triggered inflammation-related COX-2, oxidative stress-related iNOS, and HIF-2a/VEGF to cause HCMEC injury, and TXL treatment could inhibit COX-2, iNOS, HIF-2a/VEGF to antagonize the Hx-induced injury.
Whether and how Tongxinluo (TXL) modulates COX-2, PGIS, iNOS, eNOS, HIF-1a, HIF-2a, and VEGF in Hx-stimulated human cardiac microvascular endothelial cells (HCMECs) have not been clarified.