We now know that HCMV
utilises these fundamental signalling pathways to reactivate from latency.
Human cytomegalovirus (HCMV
) genotype populations in immunocompetent individuals during primary HCMV
prevalence is high in low-middle income countries, tending to be 20-30% higher in non-white than in white populations.6,7
(13,14) The objective of the present study was to study viral replication and serological response in the first three months after kidney transplantation in patients undergoing universal prophylaxis or preemptive therapy and correlate the findings with the clinical course of HCMV
Through a questionnaire-based survey, we aimed at assessing level of knowledge of HCMV
infection and its consequences and prevention in pregnant women in order to estimate the need of information campaigns, with the final aim of reducing primary infections in pregnancy.
Abbreviations ADV: Adenovirus ANA: Antinuclear antibody BPAR: Biopsy-proven acute rejection DSA: Donor-specific HLA-antibody HCMV
: Human cytomegalovirus DMSO: Dimethylsulfoxide DSMB: Data safety monitoring board EBV: Epstein-Barr virus INR: International normalized ratio IS: Immunosuppression ICU: Intensive care unit ISCT: International Society of Cellular Therapy LDLT: Living-donor liver transplantation LKMA: Anti-liver-kidney microsomal antibody LT: Liver transplantation MDSC: Myeloid-derived immunosuppressive cell MSC: Mesenchymal stem (stromal) cell pLT: Pediatric liver transplantation RI: Resistance index RT-PCR: Reverse transcription polymerase chain reaction TA Vmax: Time-averaged maximum velocity SAE: Severe adverse event SMA: Anti-smooth muscle antibody.
The 72-kilodalton IE-1 protein of human Cytomegalovirus (HCMV
) is a potent inducer of connective tissue growth factor (CTGF) in human dermal fibroblasts.
Of the approximately 120 identified different herpes virus, eight major types are known to infect human namely Herpes simplex virus (HSV) type 1 and 2, Varicella--Zoster virus (VZV), Epstein - Barr virus (EBV), Human cytomegalovirus (HCMV
), Human herpes Virus- 6 (HHV-6), Human herpes virus-7 (HHV-7), Human herpes virus-8 (HHV-8).
The vast majority of viral miRNAs are encoded by the herpesviruses family including pathogens such as, EBV, herpes simplex viruses (HSVs), human cytomegalovirus (HCMV
), Kaposi's sarcoma herpes virus (KSHV), and MHV 68.
As uncovered in the past years, artemisinin-type compounds are also active against cancer cells, human cytomegalovirus (HCMV
) infections, and other viral infections, as well as schistosomiasis (Efferth, 2005; Efferth et al., 2008; Liu et al., 2011; Efferth and Krishan, 2016) (Fig.
At the next steps of this project, we are going to evaluate the expression efficiency of this codon- optimized gene which is currently under the human cytomegalo virus (hCMV
) promoter, through pIRES- EGFP vector, in the chicken embryo fibroblast cells.
The human cytomegalovirus (HCMV
) is a double-stranded DNA virus that belongs to the Herpesviridae family.