After a thorough evaluation, belimumab was started according to the SLE guidelines, which consider that in a refractory and corticosteroid-dependent disease form, despite HCQ
and at least two consecutive immunosuppressant drugs, a biological treatment could be prescribed (5).
She was prescribed HCQ
(200 mg twice daily) and prednisone (30 mg once daily).
 Nonstandard abbreviations: RPL, recurrent pregnancy loss; APS, antiphospholipid syn drome; SLE, systemic lupus erythematosus; aPL, antiphospholipid antibody; LA, lupus anticoagulant; PT, prothrombin time; APTT, activated partial thromboplastin time; DRVVT, dilute Russell's viper venom time; HELLP, hemolysis, increased liver enzymes, low platelets; EULAR, European League Against Rheumatism; LMWH, low-molecular weight heparin; HCQ
Ubogi zasob polskojezycznych metod dotyczacych humoru i niemal znikome zainteresowanie polskich badaczy problematyka humoru w srodowisku pracy sktonity autorow niniejszego artykutu do adaptacji HCQ
autorstwa amerykanskiego zespotu badawczego.
is known to cause retinal damage in some patients, binding to and accumulating in the retinal pigment epithelium melanin.
(11) showed that perifoveal retinal ganglion cell-inner plexiform layer (RGC-IPL) thickness decreased in patients who had been taking HCQ
for a long time before any functional or structural impairment occurred in retinal pigment epithelium layer and photoreceptors.
The patient was started on intravenous ceftriaxone and azithromycin for CAP and HCQ
and pulse methylprednisolone for the SLE flare.
is an antimalarial agent that has been used for many years in treating inflammatory rheumatic diseases, especially SLE and rheumatoid arthritis.
As several of the patients had had multiple pregnancies, the association between HCQ
use and pregnancy outcomes as well as pregnancy duration was analyzed using generalized estimating equations (GEE), correcting for patient dependency of observations, using an exchangeable correlation structure.
should be continued throughout pregnancy in mothers with SLE.
MTX, azathioprine (AZA), MMF, cyclosporine, and other calcineurin inhibitors should be considered in cases of arthritis, cutaneous disease, serositis, vasculitis, or cytopenias if HCQ
Several clinical trials have studied the efficacy and toxicity of HCQ
and colchicine (though not in the same trial).