The objective of this review is to outline the prognostic factors that affect outcome in the salvage setting, the data supporting both salvage chemotherapy strategies (CDCT and HDCT
), and an ongoing randomized clinical trial that seeks to definitively establish one of these approaches as the standard of care in the initial salvage setting.
We included all clinical studies that had patients with relapsed Ewing's sarcoma who were treated with HDCT
followed by ASCT using either bone marrow or peripheral blood stem cell rescue regardless of treatment settings.
To save the space, we only consider the most recent thirteen models: FT , HC , RC , LR , PD , GC , HI , GMR , BMS , UFO , AMC , HDCT
, and SO .
The use of autologous hematopoietic cell support derived from peripheral blood progenitor cells following HDCT
is summarized in Figure 1.
Hence, the aim of this study was to assess whether total PV ostial diameter and volume assessed by HDCT
are larger in patients with AFib prior to RFCA compared to controls with sinus rhythm (SR), as those parameters may provide a noninvasive tool for risk stratification of AFib recurrence after RFCA.
IMN: How can clinicians distinguish JHS from other HDCTs
, such as Ehlers-Danlos syndrome?
 Nonstandard abbreviations: HER, human epidermal growth factor receptor; EGFR, epidermal growth factor receptor; ECD, extracellular domain; MMP, matrix metalloproteinase; Mab, monoclonal antibody; MBC, metastatic breast cancer; OS, overall survival; IHC, immunohistochemistry; FISH, fluorescence in situ hybridization; FDA, Food and Drug Administration; PBC, primary breast cancer; CISH, chromogenic in situ hybridization; TTP, time to progression; DFS, disease-free survival; HDCT
, high-dose chemotherapy; ER, estrogen receptor; CMF, cyclophosphamide-methotrexate-5-fluorouracil; and CEA, carcinoembryonic antigen.
High dose chemotherapy (HDCT
) with peripheral stem cell support has been evaluated for the treatment of many high risk paediatric tumours [8-11].
Impressive results have been reported using either conventional-dose chemotherapy (CDCT) or high-dose chemotherapy with stem cell rescue (HDCT
).[sup.1]-[sup.4] However, these reports from single institutions are confounded by patient selection.
Cardiac toxicity, with the development of left ventricular dysfunction, may be a late complication in patients treated with high-dose chemotherapy (HDCT
), especially when anthracyclines are used (19).
High-dose chemotherapy (HDCT
) with autologous hematopoietic support in metastatic germ cell tumours (GCTs) has been investigated for over 25 years.