HDMP

AcronymDefinition
HDMPHealth Data Management Partners
HDMPHigh-Dose Methyl Prednisolone
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References in periodicals archive ?
If those are not available, HDMP + R or alemtuzumab [+ or -] R can be tried.
FCR (fludarabine, cyclophosphamide and rituximab); B = bendamustine; Chl = chlorambucil; R = rituximab; Obi = obinutuzumab; Ofa = ofatumumab; A = alemtuzumab; HDMP (high dose methylprednisolone).
After the diagnosis of AA, ATG could not be given to 9 patients; instead they were given HDMP treatment.
Severity of Treatment Response Treatment Response Treatment disease group (n) group (n) group HDMP hATG + CsA rATG + CsA (1st (2nd course) course) Moderate (n 3 - 5 2 3 = 6) Severe (n = 3 - 3 - 3 6) Very 3 2 4 1 1 severe (n = 6) 2 3 Severity of Response Overall disease (n) responsenn =14 * Moderate (n 1 3 = 6) Severe (n = 1 1 6) Very - 3 severe (n = 6) 2 %50 * The 4 patients that died during the first month of treatment were excluded In the patients that responded to 1ST the time required for partial or complete response was analyzed.
Despite the fact that the patients in the present study that responded to HDMP had very severe group AA, among those that responded to ATG and CsA, 3 had moderate AA, 1 had severe AA, and 1 had very severe AA.
Combined IST with ATG, CsA, and low-dose methylprednisolone was an effective treatment option for our pediatric patients without an HLA-identical donor; however, in patients that cannot be given ATG HDMP treatment can be used as an alternative to 1ST, as it is an inexpensive and safe treatment Option.
of patients 25 25 10 3 1 PC x[10.sup.9]/L 6 (1-30) 9 11 4 37 * (4-45) (8-22) (3-8) Bleeding 25 20 7 1 0 manifestations ** Treatment/no respom IVIG or HDMP 24/3 22/4 8/0 2/0 0 IVIG or HDMP 3/0 4/0 0 0 0 No treatment 1/- 3/- 2/- 1/- 1/- * Data are presented as median (range) ** Bleedjng manifestations were all minor manifestations.
Based on the experimental studies on induction of differentiation of mice myeloid leukemic cells, we first demonstrated morphologic evidence of in vivo differentiation of myeloid leukemic cells to mature granulocytes in a boy with AML-M4 treated with HDMP alone in 1991 [45].
Short-course HDMP treatment-induced apoptosis of myeloid leukemic cells in vivo
We have also shown that induction of apoptosis of myeloid leukemic cells with or without differentiation is possible with HDMP treatment in vivo and in vitro [26,49,51].
Therapeutic effects of HDMP in children with AML Effect of HDMP on blast cells
During our long-term clinical studies, in a short-period (24 or 48 hours) after administration of HDMP treatment alone, dramatic clinical improvement (improved activities; resolution of bone pain and unexplained high fever) was observed in most of the AML children who had not received HDMP previously.