HEPT

AcronymDefinition
HEPTHamster Egg Penetration Test (fertility)
HEPTHigh Energy Plasma Thrower (X3: Reunion; video game)
HEPTHigh Event Product Tour
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Hept. no[??]ar -i as native an[??]rop-i 'notary.MASC-NOM.PL' men' vs.
Abbreviations ACC accusative DEF definite FEM feminine Hept Heptanesian INDEF indefinite It Italian MASC masculine NEU neuter NOM nominative PL plural SG singular SMG Standard Modern Greek Tr Turkish Ven Venitian VOC vocative Angela Ralli & Marianna Gkiouleka & Vasiliki Makri, University of Patras
Many efforts have been made to model the anti-HIV activity of HEPT derivatives in the past using 2D, 3D, and holographic (HQSAR) methods
Quantitative structure activity relationship studies were carried out in order to build models for the estimation of binding affinities ([DELTA][G.sub.b]) of HEPT and nevirapine analogues with reverse transcriptase [14].
In continuation to these studies we now report modeling of anti-HIV activity of 1-[2-Hydroxyethoxy) methyl]6-(phenylthio)-thymine (HEPT) derivatives (Figure 1) using graph theoretical descriptors in which distances and connectivity have been considered.
Inter girls - Hept (80H, HJ, SP, 200, LJ, JT, 800): 1 K Marchant (W Yorks) 4521; 2 J Hansom (North'd) 4294 (11.9, 1.60, 9.38, 26.0, 5.46, 21.71, 2:49.3); 3 S Brookes (W Yorks) 3948; 5 N Burlinson (Dur) 3418 (27.2 200, 4.74 LJ, 2:25.0 800); 10 C Sadler (North'd) 2898; 12 K Johnson (North'd) 2670; 13 J Wood (Dur) 2666.
Current British number one hept athlete Jessica Ennis saw her career blossom after winning the English Schools high jump title.
Summary: Quantitative structure-activity relationships were constructed for 107 inhibitors of HIV-1 reverse transcriptase that are derivatives of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT).
The SVM technique was adequate to produce an effective QSAR model and outperformed those in the literature and the predictive stages for the inhibitory activity of reverse transcriptase by HEPT derivatives.
Compound 6a: [sup.1]H NMR (500 MHz, CD[Cl.sub.3]): [delta] 1.20 (d, 6 H, J = 7.0 Hz, C[H.sub.3], i-Pr), 3.21 (hept, 1 H, J = 7.0 Hz, CH, i-Pr), 5.50 (br s, 1 H, OH), 6.61 (d, 1 H, J = 8.6 Hz, H-5), 7.11 (dd, 1 H, J = 2.4 Hz, J = 8.6 Hz, H6), 7.28 (d, 1 H, J = 2.4 Hz, H-2).
Compound 7: [sup.1]H NMR (500 MHz, CD[Cl.sub.3]): [delta] 1.08 (d, 18 H, J = 7.5 Hz, C[H.sub.3], TiPS), 1.25 (hept, 3 H, J = 7.5 Hz, CH, TiPS), 3.95 (s, 2 H, C[H.sub.2], Bn), 6.69 (d, 1 H, J = 8.5 Hz, H-5), 7.09 (d, 1 H, J = 2.6 Hz, H-2), 7.15 (m, 3 H, CH, Bn), 7.16 (dd, 1 H, J = 2.6 Hz, J = 8.5 Hz, H-6), 7.25 (m, 2 H, CH, Bn).