HET-CAM

AcronymDefinition
HET-CAMHen's Egg Test Chorioallantoic Membrane
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References in periodicals archive ?
Prepared OCM-CSNPs were nonirritant when tested by HET-CAM. In vivo studies of DRZ loaded OCM-CSNPs exhibited a promising prolonged antiglaucoma effect without pulse entry as compared to CSNPs.
The authors are thankful to TIFR, Mumbai, India for X-ray diffraction, Nair Hospital, Mumbai, India for HET-CAM and IIT Bombay, India for TEM studies.
De Silva, "The HET-CAM, a useful in vitro assay for assessing the eye irritation properties of cosmetic formulations and ingredients," Toxicology in Vitro, vol.
TABLE 3: Irritation scores and interpretations used in HET-CAM test.
Comparative study of the Het-Cam test and the Draize eye test for assessment of irritancy potential.
Validation study of alternatives to the Draize eye irritation test in Germany: cytotoxicity testing and HET-CAM test with 136 industrial chemicals.
The aim of this study was to evaluate the possibility of using the HET-CAM assay as an in vitro alternative method to the in vivo vaginal irritation test in rabbits.
The application of the HET-CAM assay to vaginal irritation testing is therefore in line with the 3Rs policy.
The use of the HET-CAM assay for vaginal product testing widens the safety assessment portfolio that can be applied to test substances or products in a faster and more effective way in the first steps of preclinical safety testing.
K-Y[R] Jelly and Ginix Plus[R], that are herein considered HET-CAM borderline products, had previously demonstrated higher cytotoxicities (Cunha et al., 2014).
Our research group has previously reported osmolality results for the medicinal products and lubricants tested herein (Machado et al., 2017) and found that some that showed higher IS in the HET-CAM assay were also highly hyperosmolal, i.e., Lomexin[R] (1446 [+ or -]20 mOsmol/kg), Colpothrophine[R](1723 [+ or -]20 mOsmol/kg), Geliofil[R] (3582 [+ or -]11 mOsmol/kg), Vidermina[R] (3707 [+ or -]16 mOsmol/kg), and K-Y[R] Jelly (3631 [+ or -]13 mOsmol/kg) were highly hyperosmolal, all above the upper limit recommended by the WHO (1200 mOsmol/kg) (WHO, 2012; Machado et al., 2017).
Together, these findings strengthen the hypothesis that product osmolality and cellular and tissue toxicity could be highly predictive of irritation potential and suggest that these techniques (HET-CAM, osmolality, cell/tissue metabolic toxicity) should be applied concomitantly for a more robust clinical irritation response prediction.