With the same HFHSD, FBG levels in obese pigs steadily and rapidly increased over 30 weeks.
Our data showed obese pigs induced by HFHSD for 30 weeks showed elevated IL-6 levels and insulin resistance, supporting this speculation to a certain extent.
This model well established that AMPK impairment induced by adiponectin decrease mediated insulin resistance in HFHSD induction, providing a useful tool for assessing insulin sensitivity and diabetes.