HGAINHigh Grade Anal Intraepithelial Neoplasia
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HPV infection, in conjunction with other yet to be determined factors, leads to the development of high-grade anal intraepithelial neoplasia (HGAIN), which is a probable precursor to anal cancer.
In cases diagnosed with HGAIN through directed biopsies, an ablation of HGAIN lesions must be done.
When abnormal, patients are referred for high-resolution anoscopy and biopsy of lesions suspected of HGAIN. HGAIN areas are removed by ablation to reduce the risk of progression into anal cancer.