HGDN

AcronymDefinition
HGDNHigh-Grade Dysplastic Nodules
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References in periodicals archive ?
Useful Immunomarkers for Distinguishing Well-Differentiated Hepatocellular Carcinoma (WDHCC) From Hepatocellular Adenoma (HCA) and High-Grade Dysplastic Nodule (HGDN) Marker WDHCC, % HCA, % HGDN, % Glypican-3 50-69 0 <10 Glutamine 35-60 10-15 <15 synthetase (strong and diffuse) Heat shock 40-78 0 <10 protein 70 Positive in at 50-72 0 0 least 2 of the above 3 markers CD34 (diffuse 95 (a) 20 +/- sinusoidal pattern) Clusterin 75 0 No data (enhanced canalicular pattern) CK7 Absence of No value Presence of ductules at ductules at border border (invasive (noninvasive growth) growth) Abbreviations: CK, cytokeratin;+/-, may or may not.
(153) High-grade DNs (HGDNs) show at least moderate cytologic or architectural atypia, but the abnormalities are insufficient for the diagnosis of HCC.
Di Tommaso et al (128) compared 22 HGDNs with 32 early or well-differentiated HCCs, and found GPC3, GS, and HSP70 expression in 69%, 59% and 78% of HCCs, in contrast to 9%, 14% and 5% of HGDNs, respectively.