HGFRHepatocyte Growth Factor Receptor
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MET is a RKT belonging to the family of hepatocyte growth factor receptor (HGFR), it binds HGF/SF (hepatocyte growth factor/scatter factor).
lymph nodes metastasis MET It is a RKT belonging to It is associated It is an important the family of Hepatocyte with predictive Growth Factor Receptors (i) more aggressive biomarker of the (HGFR); it binds HGF/SF.
The MET gene encodes for the receptor for hepatocyte growth factor (HGFR), and its activation has pleotropic functions in promoting cell survival, proliferation, motility, invasion, and epithelial-mesenchymal transition.
Both biological and technical variability could have influenced the test performance, since CTC might change their phenotype during hematogenous dissemination, losing some epithelial markers, and the panel of surface antigens beyond EPCAM, as ERBB2, MUC1, EGFR, and HGFR, currently exploited to identify CTC by immunological methods, might still be incomplete.