HGPIN

AcronymDefinition
HGPINHigh-Grade Prostatic Intraepithelial Neoplasia
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HGPIN is identified on prostate biopsies in the absence of invasive carcinoma with a frequency of about 5%, although there is much variability in the incidence rate with reports ranging up to 25%.
According to researchers, this trial does not support the hypothesis that combination vitamin E, selenium and soy prevents progression from HGPIN to PCa.
Recent studies have shown that IDCP is genetically different from HGPIN in terms of greater loss of heterozygosity and, occasionally, a greater frequency of ERG rearrangements than found in invasive cancer.
CK5 helps to define the integrity of the basal cell layer, so the pathologist can confirm the existence of high-grade prostatic intraepithelial neoplasia (HGPIN); even if cancer is not found in the biopsy, ERG positive HGPIN gives strong support for the existence of prostate adenocarcinoma within a few millimeters of the biopsy due to a 'field affect.
Although most IDC-P is thought to be a late-stage phenomenon in high-grade, high-stage prostate cancer, there is some evidence that, at least in a small subset of patients, IDC-P may represent a precursor lesion that has progressed beyond HGPIN but before invasive carcinoma has developed.
P504S is upregulated in prostate carcinomas and HGPIN, and can serve as a positive tissue marker; however, by itself, P504S positivity is not specific as it may also be expressed in benign mimickers such as atypical adenomatous hyperplasia and nephrogenic adenoma.
Univariate and multivariate analysis was performed to identify the predictive significance of age, preoperative PSA, PSA density, number of biopsy cores, PCBM and the presence of HGPIN.
Each ECPB was classified according to the highest lesion diagnosed in any of the parts of the ECPB specimen (cancer > ASAP > HGPIN > benign).
A univariate analysis was performed to identify the predictive significance of age, preoperative PSA, prostate volume, PSA density, preoperative first and second Gleason pattern, Gleason summary, number of biopsy cores, PCBM and the presence of HGPIN in biopsy cores in prediction of prostate cancer unilaterality.