HGPRHepatic Glucose Production Rate
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It is well known that hereditary hyperactivity of the purine synthesis enzyme PRPP (5-phospho-D-ribosyl-1-pyrophosphate) synthase can lead to hyperuricemia, as can partial deficiency of HGPR (hypoxanthine-guanine phosphoribosyl) transferase, the rate-limiting step in the purine salvage pathway.