HHV-6Human Herpes Virus Type 6
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(16) The histopathologic findings for HHV-6 and HHV-7 cutaneous infections are nonspecific and related to the disease process, not the virus.
Other viruses such as herpes simplex, influenza A and rabies can invade the brain by shooting through the nose, so Jacobson and his team wondered whether HHV-6 could do the same.
In two of three brain tissue samples, researchers found HHV-6 in high levels around the olfactory bulb, a part of the brain oriented toward smell.
Although not the focus of this editorial, there is substantial evidence of the association between MS and other viruses; serological evidence of an association between MS and HHV-6 is well described.
HHV-6 infection was monitored using polymerase chain reaction on saliva samples obtained weekly by parents using precut filter-paper strips.
Blauvelt, who is an investigator in the dermatology branch of the National Cancer Institute at NIH; and his associates extracted DNA from samples of blood, saliva, and skin from 14 patients with acute pityriasis rosea, 10 with psoriasis, and 12 healthy controls and then used polymerase chain reaction analysis to look for HHV-6, HHV-7, CMV, and [beta]-globin.
The 1-step PCR technique was designed by researchers at the Institut de Biologie des H(tm)pitaux de Nantes (France) to avoid the detection of latent HHV-6 infection and to enhance the ability to diagnose active infection.
The ABC news story on the HHV-6 link to MS did not put the scientific study they cited into context.
Caroline Breese Hall, chair of the American Academy of Pediatrics, committee on infectious diseases, new serological studies-research on our blood - indicate that nearly everyone becomes infected with HHV-6 before age three.
(16) Reservoirs of CMV have been found in nasal mucosa, trachea, and thyroid; EBV in nasal mucosa, tonsils, and lymph nodes; and HHV-6 in salivary glands and thyroid.