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HHV8Human Herpes Virus 8 (causative agent of Kaposi''s sarcoma)
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Periaortic lymph node biopsy showed human herpes virus 8 (HHV8) associated Castleman's disease and marked vascular proliferation (Figure 1).
Caption: Figure 2: Immunohistochemical studies performed on thyroid gland revealed that the neoplastic lymphoid cells are positive for CD20 ((a), 20X), dim CD79a ((b), 20X), MUM1 ((c), 20X), and CD5 ((d), 20X); negative for CD10 ((e), 20X), HHV8 ((f), 10X), EBER ((g), 10X), c-MYC, BCL6, and cyclin D1 (not shown).
The herpesviruses CMV, VZV, HSV1, HSV2, and HHV8 were not found in any of the saliva samples.
PCR blood test did not reveal viral replication for CMV and HHV8. Exhaustive immune tests were also not contributive, and the serum complement was normal.
Immunostaining for cyclin D1 and HHV8 was negative in these cells with a low proliferating index of Ki67 (<1%).
Human herpes virus 8 (HHV8)/Epstein-Barr virus- (EBV-) associated germinotropic lymphoproliferative disorder (GLD) is a rare entity that has been described in HIV seronegative patients [1].
They were negative for CD20, CD79, CD19, cyclin D1, ALK, HHV8, CD2, CD3, CD4, CD5, CD8, CD33, CD43, EMA, Cytokeratin, and S-100.
The international literature also reports hepatitis viruses E and G, human immunodeficiency virus, the West Nile virus and HHV8.
[1] It is a tumour of the blood and lymphatic vessels caused by the infectious agent human herpesvirus 8 (HHV8 or Kaposi's sarcoma virus).
EBV (HHV4) and KSHV (HHV8) belong to the Herpesviridae family.