Both public and private providers will be able to order some additional doses of Hib
vaccine each month, with allotments based on previous purchasing patterns or the size of the practice's birth cohort and estimates of additional needs.
disease is difficult; Hib
primarily causes meningitis and pneumonia, two common syndromes often treated empirically.
This has led to cases of Hib
falling dramatically and almost disappearing in young children.
Outcome was known for 86% of the total 197 Hib
cases reported during 1998-2000.
During the Hib
shortage, children received protection from certain vaccine preventable diseases in their primary vaccination series through various permutations of available combination vaccines (e.g., DTaP-IPV/Hib [Pentacel] and DTaP-IPV-HepB [Pediarix]) and monovalent vaccines (e.g., ActHib, HepB, and IPV).
Because of the importance of Hib
in invasive disease, vaccination efforts have concentrated on the b serotype (16).
"Progress towards further reducing the global burden of Hib
and pneumococcal disease burden will depend on the efforts of a few large countries in Africa and Asia," the authors write.
response after the fourth dose also was demonstrated to be noninferior to HibPRP-OMP (the percentage of subjects with anti-HibPRP antibody concentrations [greater than or equal to] 1.0 [micro]g/mL was 99.2% in both treatment groups).
As a condition of the accelerated approval, GSK will conduct a postmarketing study of Hiberix in the United States, which will evaluate the safety and immunogenicity of Hiberix as a booster and primary vaccine, compared with an Hib
vaccine that is already available in the United States, according to the statement.
From 1999, the number of Hib
cases increased in all age groups, particularly in children under five years.