In the study of expression profile of CRC, we found that high expression of MBD1 was closely related to genes in chromosomes 17P12 and 17P13 and the two chromosome zones included many known tumor suppressor genes, such as HIC1
, VPS53, RPA1, ALOX15B, TP53, PFN1, MYBBP1A, and GABARAP.
Hokland, "Promoter hypermethylation of p15INK4B, HIC1
, CDH1, and ER is frequent in myelodysplastic syndrome and predicts poor prognosis in early-stage patients," European Journal of Haematology, vol.
In August it received the OK for a generic version of Urispas (flavoxate HIC1
) 100-mg tablets, which are marketed for the symptomatic relief of various urinary tract conditions.
For example, Achille and collaborators investigated global DNA methylation and gene expression of CDKN2A (cyclin-dependent kinase inhibitor 2A), CDKN2B (cyclin-dependent kinase inhibitor 2B), both regulators of the cell cycle at the G1 checkpoint; HIC1
(transcriptional repressor 1), a growth regulatory molecule that acts as a tumor repressor; RARB (retinoic acid receptor beta), a retinoic acid nuclear receptor which also mediates cellular signalling, growth, and differentiation; CDH1; and APAF1 (apoptotic peptidase activating factor 1), an apoptosis initiator by cleavage of caspase 9, before and during hypomethylating therapy, with the purpose of observing whether early changes could predict clinical response.
In another model, epigenetic silencing of HIC1
(hypermethylated in cancer 1) resulted in a partial loss of p53 function, cooperating to drive tumor growth and progression .
Zhang et al., "Hypermethylation of HIC1
promoter and aberrant expression of HIC1/SIRT1 might contribute to the carcinogenesis of pancreatic cancer," Annals of Surgical Oncology, vol.
DNA Methylation and Patient Outcome.--DNA methylation status of individual genes, such as those encoding a transcriptional repressor (HIC1
), a proapoptotic protein (PYCARD), a tumor suppressor (LZTS1), and a transporter (SLC6A20), has been associated with either a good or poor prognosis.
Hypermethylated in cancer 1 (HIC1
) is a tumor suppressor gene that cooperates with p53 to suppress cancer development.