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HIF1Hypoxia Inducible Factor 1 (gene expression)
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References in periodicals archive ?
Bioactive flavonoids and catechols as Hif1 and Nrf2 protein stabilizers--Implications for Parkinson's disease.
It is important that the MDR1 and MRP genes are targets for transcription factor HIF1 (36).
Denko, "Hypoxia, HIF1 and glucose metabolism in the solid tumour," Nature Reviews Cancer, vol.
SIRT3 opposes reprogramming of cancer cell metabolism through HIF1 destabilization.
In tumors, however, hypoxia which is often present in the central areas that are not well-vascularized synergistically interacts with IFN-a to induce iNOS expression through the physical interaction between HIF1 and IRF-1.
For the first time, nuclear medical molecular imaging of HIF1 activity in vivo has been performed using a HIF-1-dependent reporter system.
Lin et al., "Autophagy in cancer associated fibroblasts promotes tumor cell survival: role of hypoxia, HIF1 induction and NFkB activation in the tumor stromal microenvironment," Cell Cycle, vol.
A central role for the regulation of many of these mechanisms has a substance called hypoxia inducible factor 1[alpha] (HIF1 [alpha]) (6).
Citation: "HIF1" induced switch from bivalent to exclusively glycolytic metabolism during ESC-to-EpiSC/ hESC transition;" Wenyu Zhou, Hannele Ruohola-Baker et al.; The EMBO Journal, 20U; DOI: 10.1038/emboj.2012.71
HIF1 alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion.
HIF1 is a target of the PI-3K/Akt signaling pathway which could be controlled by PTEN gene loss/mutation through increasing the PIP3 level under hypoxic conditions (4).