AKB4924, a HIF1
stabilizer, is in late preclinical development for inflammatory bowel disease.
53) Damage-activated HSCs are thought to reduce mitochondrial respiration and biogenesis through hypoxia-induced HIF1
In the yak, the upregulated expression of IGF-1 can induce HIF1
expression, and hence, trigger various genes to express and regulate the cellular hypoxia response (Fukuda et al.
MiR-199a suppresses the hypoxia-induced proliferation of non-small cell lung cancer cells through targeting HIF1
Hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) (HIF1A)/aryl hydrocarbon receptor nuclear translocator (ARNT) pathways, required for angiogenesis, are also activated in basal-like tumors, suggesting that HIF1
inhibitors or bioreductive drugs that become activated under hypoxic conditions may benefit patients with basal-like cancers.
Existe una serie de eventos bajo los cuales la angiogenesis puede iniciarse, la cual esta determinada por un balance de factores pro-angiogenicos y anti-angiogenicos, donde la hipoxia juega un rol primario como disparador de la misma al incrementar la actividad de HIF1
, y por tanto los niveles de VEGF.
Sirt6 has only deacetylase activity, binds HIF1
to promoter targets, and modulates glycolytic genes by H3K9 deacetylation .
c-Myc induces the activation of the PGC-1[beta] factor; on the other hand, mitochondrial biogenesis is inhibited when HIF1
factors promote degradation of c-Myc .
When a second, inactivating event affects the remaining wild-type VHL allele, loss or alterations of the VHL protein causes activation of the HIF1
hypoxia signal pathway, which likely leads to tumor formation.
within the same cancer type, elesclomol is less active in cell lines with high levels of HIF1
(hypoxia inducible factor 1 alpha) and LDH, markers of hypoxic conditions; and more active in cells with low levels of HIF1