HIOMTHydroxy-Indole-O-Methyl Transferase (enzyme)
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No influence of LPS on HIOMT protein and gene expression was found for either photoperiod (Figure 5; panel D).
Both of these are substrates for HIOMT and yield 5-methoxyindole acetic acid and 5-methoxytryptophol, respectively [21].
It has also been suggested that inflammation may influence melatonin secretion by affecting HIOMT expression and activity.
Simonneaux, "HIOMT drives the photoperiodic changes in the amplitude of the melatonin peak of the siberian hamster," American Journal of Physiology-Regulatory Integrative and Comparative Physiology, vol.
Simultaneous changes of the perivascular contact area and HIOMT activity in the pineal organ after bilateral adrenalectomy in the rat.