HLA-DQ


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AcronymDefinition
HLA-DQHLADC Histocompatibility Type
References in periodicals archive ?
The incidence of HLA-DQ2/DQ8 in Turkish children with celiac disease and a comparison of the geographical distribution of HLA-DQ. Prz Gastroenterol 2017; 12:256-61.
The ultimate T cell epitopes were obtained by combining the results of the HLA-DR alleles epitopes and HLA-DQ alleles epitopes.
23 A24:02 B40:02 :01 A26:01:01 B48:01 :01 2 54 47 A31 B60/B55 3 125 86 A2/A31 B7/B40 4 94 69 Ail B54(22)/ B35 5 102 46 A24/A26 B7/B56 HLA Case HLA-C HLA-DQ HLA-DR DQA1*03 :01 : 01 DRB1*04:05 1 C03:04:01 DQA1*03 :03 DRB1*08:02 DQB1*03 : 02 : 01 DPB1*02:02 C08:03 :01 DQB1*04:01 : : 01 DPB1*05:01 2 - DQAl'01 DRB1*04 DRB1*14 3 - DQA1*03 DQB1*05 DRB1*01 DQB1*04 DRB1*04 4 Cwl/Cw3 - DR4 5 C0401 - DRBl*01 C0702 DRB1*04 n.d.: not done; [beta]2-MG: [beta]2 microglobulin.
The search strategy was based on a combination of "HLA-DQ," "hepatitis B virus," or "HBV"; "Hepatocellular carcinoma," "HCC," or "liver cancer"; "polymorphism" or "SNP"; and "rs2856718" or "rs9275572" (up to March 27, 2017).
A transcriptome study showed that the A allele of rs7453920 was associated with higher HLA-DQ mRNA levels in circulating monocytes, which are critical for mounting immune responses [10].
These proteins are encoded by highly polymorphic HLA-DQ genes located at HLA class II loci on the short arm of chromosome 6 (6p21.3).
For HLA-DQ alleles, NetMHCII-2.2 (http://www .cbs.dtu.dk/services/NetMHCII/) [38] was used.
Studies from around the world using dioxyribonucleic acid (DNA) typing methods have proved that 95% of CD patients have a particular pair of HLA-DQ alleles with a combination of DQA10501 and DQB10201 alleles which are located in cis position in DR3 positive individuals and in trans position in DR7/DR5 positive individuals.4-7 However, HLA-DR alleles involved vary when different ethnic groups are considered.
Celiac disease has a strong relation to testing positive for the HLA-DQ gene, perhaps explaining not only its genetic predominance but also its connection to certain other diseases, such as type 1 diabetes, which also has an increased prevalence in individuals with positive HLA-DQ typing.
With human leukocyte antigen (HLA) matching, he had single antigen mismatches at the HLA-A, HLA-B and HLA-DQ loci, two antigen mismatches on the HLA-DR and DRW loci and no mismatches on the HLA-C locus.