HLA-DRAMajor Histocompatibility Complex, Class II, DR Alpha
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References in periodicals archive ?
Cornejo-Garcia et al., "HLA-DRA variants predict penicillin allergy in genomewide fine-mapping genotyping," The Journal of Allergy and Clinical Immunology, vol.
The MHC II binding site is formed by 35 amino acids from the N-terminal 80 and 90 residues of the HLA-DRA and HLA-DRB, respectively [52, 55, 62].
Caption: FIGURE 3: Docking of the epitope with HLA-DRB1*0101 (a), HLA-DRB1*0901 (b), HLA-DRB1*0404 (c), HLA-DRB1*0701 (d), HLADPB1* 0101 (e), HLA-DQB1* 0301 (f), and HLA-DRA (g).
Notably, the scales of the odds ratio for rs7568275 (STAT4: O[R.sub.CH] = 1.78, O[R.sub.MA] = 2.36), rs9398065 (PRDM1-ATG5: O[R.sub.CH] = 1.97, O[R.sub.MA] = 3.31), rs5029928 (TNFAIP3: O[R.sub.CH] = 1.88, O[R.sub.MA] = 1.96), and rs76404385 (ETS1: O[R.sub.CH] = 1.59, O[R.sub.MA] = 3.25) were very close to HLA-DRA levels of OR (rs6911777 O[R.sub.CH] = 2.26, O[R.sub.MA] = 3.32).
We derived four causal SNPs that potentially explain enrichment of this pathway, where rs2071554 (nonsynonymous, coding (deleterious) in HLA-DOB) and rs1129740 (nonsynonymous, coding in HLA-DQA1) are candidate causal SNPs through their RECEPTOR_ACTIVITY/TRANSMEMBRANE_RECEPTOR_ACTIVITY; rs8084 (essential splice site and intronic in HLA_DQB) and rs7192 (nonsynonymous, coding in HLA-DRA) were candidate causal SNPs through TRANSMEMBRANE_RECEPTOR_ACTIVITY.
Interestingly, we also found no differences for HLA-DRA and CD74, which are associated with the MHCII.
Similarly, we found the postoperative production of HLA-DRA mRNA in both groups to be reduced compared with preoperative values, a finding that reflects the situation before and after an inflammatory stimulus.
To control the extraction efficiency of DNA from stool, two capture oligonucleotides from HLA-DRA were designed as perfect-match (PM) and mismatch (MM) probes.
Significant inhibition of the PCR reaction by remaining impurities was not observed, as indicated by our successful amplification of HLA-DRA.
To control the effectiveness of the DNA-extraction procedure, a human control gene, HLA-DRA, was coamplified in a duplex PCR protocol.
In addition, the amplification of the HLA-DRA control sequence was successful with all samples, indicating the reliable removal of PCR inhibitors.