HLRCCHereditary Leiomyomatosis and Renal Cell Cancer
HLRCCHiggins Lake-Roscommon Chamber of Commerce (Roscommon, MI)
HLRCCHereditary Leiomyomatosis and Renal Cell Carcinoma (genetics)
HLRCCHarold Leever Regional Cancer Center (Waterbury, CT)
References in periodicals archive ?
Patients with HLRCC should also undergo annual skin examinations by a dermatologist from eight, due to associated cutaneous leiomyomas.
Recommended assessment and followup of hereditary RCC syndromes Syndromes VHL HPRC HLRCC Gene VHL MET FH affected Renal ccRCC Papillary I RCC Papillary II RCC US of abdomen CT or MRI of MRI of abdomen Start: Age 8 abdomen Start: Start: Age 8 Freq: Once Age 18.
In the specific cases of the HLRCC and the RCC, absent the Obama Administration's domestic efforts at regulatory reform, it is unclear whether any bilateral engagement would have occurred following the Guadalajara summit in 2009.
The modest ambitions of international efforts at regulatory disciplines, such as the OECD Guidelines, and the RCC and HLRCC agendas, reflect this ambivalence, which is not solely American.
The presence of papillary architecture and cells with eosinophilic cytoplasm and high-grade nuclei, in conjunction with the fact that the classic nuclear/nucleolar features of HLRCC may be seen only focally within these tumors, might lead to HLRCC-associated RCC being considered in the differential diagnosis of t-RCC.
4) We also know that the cause of tumoural development in HLRCC is the mutation in FH.
HLRCC is a relatively rare autosomal dominant condition which causes cutaneous and uterine leiomyomas and early-onset RCC, typically papillary carcinoma type II.
The genetic basis for HLRCC syndrome is germ-line inactivating mutation in the gene for the Krebs/tricarboxylic acid cycle enzyme, fumarate hydratase (FH), located in the enzyme that converts fumarate to malate.
HLRCC has an autosomal dominant inheritance, and the FH gene is thought to act as a tumour suppressor gene.