HLRCCHereditary Leiomyomatosis and Renal Cell Cancer
HLRCCHiggins Lake-Roscommon Chamber of Commerce (Roscommon, MI)
HLRCCHereditary Leiomyomatosis and Renal Cell Carcinoma (genetics)
HLRCCHarold Leever Regional Cancer Center (Waterbury, CT)
References in periodicals archive ?
The modest ambitions of international efforts at regulatory disciplines, such as the OECD Guidelines, and the RCC and HLRCC agendas, reflect this ambivalence, which is not solely American.
4) We also know that the cause of tumoural development in HLRCC is the mutation in FH.
HLRCC is a relatively rare autosomal dominant condition which causes cutaneous and uterine leiomyomas and early-onset RCC, typically papillary carcinoma type II.
The genetic basis for HLRCC syndrome is germ-line inactivating mutation in the gene for the Krebs/tricarboxylic acid cycle enzyme, fumarate hydratase (FH), located in the enzyme that converts fumarate to malate.
HLRCC has an autosomal dominant inheritance, and the FH gene is thought to act as a tumour suppressor gene.