The company will continue to enrol HRAS mutant HNSCC
patients and plans to present data from the study at an upcoming scientific or medical conference.
As a general rule, distant, peripheral, solitary, and squamous lung lesions in conjunction with HNSCC
are thought to be metastases, and concurrent esophageal tumors are thought to be separate primary tumors.
HPV-16 infection is recognized to participate in the development of a substantial proportion of head and neck cancers and is associated with a subset of HNSCC
, especially those arising from the oropharynx (more than 80%), which are the most frequent, and the larynx (~70%).
15) Therapeutically, detection of HR-HPV in a meta-static HNSCC
of unknown primary can presumptively localize the likely origin to the oropharynx, and radiation therapy may be targeted to this region instead of being applied more widely.
Immunotherapies are about to transform HNSCC
Although cancer treatment regimens have been advanced, up to 50% of HNSCC
patients will experience recurrence or residual disease even after therapy and the median survival rate is less than 1 year (Cooper et al.
The mechanism explaining why EGFR has high expression in HNSCC
is not completely elucidated, although several hypotheses including mutations in the receptor, high ligand levels, and increased mRNA transcription have been proposed (see Figure 2) .
myeloid cells in hypoxic microenvironment of HNSCC
," Neoplasia, vol.
Paraffin embedded blocks of head and neck squamous cell carcinoma (HNSCC
) cancer tissue and corresponding normal tissue from a total of 77 sporadic cases of primary HNSCC
were obtained from Hamamatsu University Hospital (Japan).
The burden of HNSCC
is putting much pressure on the national health care systems and deprives individuals, families and society.
One saliva-based risk assessment tool for HNSCC
currently available is for oral human papillomavirus (HPV) DNA testing.
is the sixth most common type of cancer worldwide and requires a combination of surgery, radiation therapy, and/or chemotherapy.