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This is an exclusive agreement between the parties to study the combination of these two classes of investigational agents in HPV-positive HNSCC.
Key opinion leaders (KOLs) say immunotherapies will transform the head and neck squamous cell carcinoma (HNSCC) landscape.
Although resveratrol has been found to mitigate aberrant activation of STAT3 in various cell lines, our study is the first one to explore the effects of resveratrol both on STAT3 signaling cascades and on the negative regulators of phosphorylated STAT3 (SOCS-1) in HNSCC cells.
Though majority of the HNSCC can be prevented and cured if detected early, millions of victims suffer from delayed diagnosis, inadequate treatment, inappropriate rehabilitation and palliation.
One saliva-based risk assessment tool for HNSCC currently available is for oral human papillomavirus (HPV) DNA testing.
A previous study demonstrated that VPA is a potent inhibitor of proliferation in some HNSCC cell lines.
Tidyman in his study concluded that amplification of K-ras in oral cancer results in an overactive mitogenic signal which in turn results in an increased proliferative and/ or survival response contributing in the development of hNSCC.32 In another study by Avruch it was sug- gested that Epidermal growth factor receptor (EGFR) is frequently overexpressed in head and neck cancers via the Ras-Raf-MAP-kinase pathway.33 Their study also explained that activation of Raf kinase via acti- vation of Ras is thought to play an important role in premalignant lesions and carcinogenesis.
CSCs and EMT Coexistence in HNSCC. EMT is a process by which epithelial cells lose their polarity and are converted to a migrant mesenchymal phenotype.
The literature demonstrates a tendency to consider TATE as a favourable prognostic factor in head and neck squamous cell carcinoma (HNSCC), but TATE has also been related to a poorer prognosis or even to no influence on patients' outcome reflecting that this issue is still a matter of controversy [7, 8].
Between January 2010 and December 2012, 78 consecutive patients with untreated HNSCC patients underwent ND with primary HNSCC surgery performed by the same team of surgeons.
Global increase in incidence and mortality associated with head and neck squamous cell carcinomas (HNSCC) have intensified efforts in the field of research pertaining to tumor biology and therapeutics.
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