HO-1Heme Oxygenase Isozyme-1
HO-110.1152/ajprenal.00140.2001.-Heme oxygenase-1
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References in periodicals archive ?
In adipose tissues, induction of HO-1 has been shown to reduce body weight, decrease NOV, and increase PGC-1[alpha] mediated thermogenesis, thereby increasing energy uptake and the stimulation of mitochondrial FA oxidation [22].
We performed a receiver operating characteristics (ROC) curve analysis to determine the most suitable cut-off levels of serum HO-1 and other blood biomarkers for detecting an AE and predicting hospital death among patients having an AE.
Recently, elevated blood levels of HO-1 were reported in some chronic diseases, such as type 2 diabetes mellitus (DM) and Parkinson's disease [10, 11].
The aim of this current study was to verify the extensive estrogen-agonist properties of RAL in cardiovascular system with analyzing of HO-1 and HO-2 isoforms.
The siRNA HO-1 and control siRNA instructions were provided by the manufacturer (Invitrogen, Carlsbad, CA, USA).
Here, we demonstrate that HO-1 induction by hemin reduces levels of inflammatory cytokines and enhances adipose macrophage switching toward the M2 phenotype in vitro and in vivo.
They found that absence of HO-1 in these mice resulted in significant mortality due to arterial clotting; however, treatment with a CO-releasing molecule both decreased clotting and improved survival.
As for studying carbon monoxide instead of HO-1 in mice, since externally applied carbon monoxide mimicked the anti-inflammatory effects of the enzyme in the animals, the researchers hypothesize that carbon monoxide contributes to the protective action of HO-1 in multiple sclerosis.--N.
Individual HO-1 expression increases in response to oxidative stress, cytokines, heavy metals, hypoxia, or heme and is influenced by genetic variability.
Each patient was evaluated for peripheral blood HO-1, lactate dehydrogenase (normal < 225 U/L), C-reactive protein (normal < 0.3mg/dL); Pa[O.sub.2]/[F.sub.I][O.sub.2]; and lung injury score at the time of diagnosis, which was designated as D0, and at 7 days after diagnosis, which was designated as D7.
In our lab, recombinant Lactococcus lactis expressing HO-1 (LL-HO-1) were successfully constructed by genetic engineering.