HPC1Hereditary Prostate Cancer 1
HPC1Human Plasma Cell Antigen-1 (immunology)
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In general, the porosity of HPCs with fly ash (HPC1, HPC2, HPC3) was lower than that of HPC without fly ash (HPC0), which was mainly due to pozzolanic effect and microfiller effect of fly ash [29].
As seen in Figure 4, the expansion ratio of HPCs decreased quickly and then increased rapidly with the increase of erosion time, and the expansion ratio reached the minimum value at 84 (HPC0, HPC2, and HPC3) or 112 (HPC1) days, the changing trend of which was matched rather well with that of the porosity (Figure 2).
After 280 days, the expansion ratio of HPCs with fly ash (HPC1, HPC2, and HPC3) was lower than that of HPC without fly ash (HPC0), which indicated that the sulfate attack resistance of HPC couldbe improved by adding fly ash.
The compressive strength of HPC1, on the whole, was the highest before and after exposure to magnesium sulfate solution, which indicated that this kind of HPC had the strongest resistance to magnesium sulfate attack in terms of compressive strength.
Estudios moleculares han aportado evidencia sobre la posible presencia de un gen de susceptibilidad en la region cromosomica denominada HPC1 (17), donde se encuentra ubicado el gen RNASEL.
Germline alterations of the RNASEL gene, a candidate HPC1 gene at 1q25, in patients and families with prostate cancer.
Germiline mutations in ribonuclease L gene in families showing linkage with HPC1. Nat Genet 2002; 30:181-184.
In addition to the discovery of the HPC1 gene, several other theories have been developed in an attempt to explain the genetic basis of prostate cancer.
The HPC1 gene has been implicated in viral defense, and scientists have found that men with mutations in their HPC1 gene harbor this virus 30 times more than men without the genetic mutation.
The investigators sought to compare the incidence of viral infection in the 20 men in the study who had the HPC1 mutation with the incidence in the 66 men with one or no copies of the altered gene.
The screening tool identified a novel retrovirus sequence found in 9 of the 20 men with two mutated copies of the HPC1 gene, compared with only 1 of the 66 other men.