HPC1Hereditary Prostate Cancer 1
HPC1Human Plasma Cell Antigen-1 (immunology)
References in periodicals archive ?
Estudios moleculares han aportado evidencia sobre la posible presencia de un gen de susceptibilidad en la region cromosomica denominada HPC1 (17), donde se encuentra ubicado el gen RNASEL.
Germline alterations of the RNASEL gene, a candidate HPC1 gene at 1q25, in patients and families with prostate cancer.
In addition to the discovery of the HPC1 gene, several other theories have been developed in an attempt to explain the genetic basis of prostate cancer.
The HPC1 gene has been implicated in viral defense, and scientists have found that men with mutations in their HPC1 gene harbor this virus 30 times more than men without the genetic mutation.
The investigators sought to compare the incidence of viral infection in the 20 men in the study who had the HPC1 mutation with the incidence in the 66 men with one or no copies of the altered gene.
The screening tool identified a novel retrovirus sequence found in 9 of the 20 men with two mutated copies of the HPC1 gene, compared with only 1 of the 66 other men.