HPEE

AcronymDefinition
HPEESociety for Human Performance in Extreme Environments
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The validity of our finding is further supported by the fact that we found higher ORs for a longer delay ([greater than or equal to]4 h) than a shorter delay ([less than or equal to]3 h) between the HPEE and washing with soap and water when compared with no exposure to an HPEE.
In addition to HPEE, we also observed elevated OI among Iowa farmers, those ever married, current smokers, snuff users, those with head injury, and those reporting higher cumulative pesticide exposure.
Adjusted odds ratios (95% CIs) for self-reported olfactory impairment (OI) in 2013-2015 in association with a history of any high pesticide exposure event (HPEE) at enrollment (1993-1997), and with specific characteristics of the HPEE that resulted in the highest exposure, relative to OI in farmers without any history of HPEE at enrollment.
In addition, 44% (n = 22,916) of these farmers completed a take-home questionnaire that sought further details on pesticide exposure, including a history of HPEEs. The cohort has been recontacted every 5-6 y to update exposures and health status: in 1999-2003 (n = 33,457), 2005-2010 (n = 24,170), and 2013-2015 (n = 24,139).
We further conducted four sensitivity analyses to examine the robustness of study results: a) further adjusting for cumulative days of any pesticide use because farmers who reported HPEEs were also more likely to report higher occupational use of pesticides (Alavanja et al.
For HPEEs that occurred after the 1999-2003 survey but before the 2005-2010 survey, we estimated associations with OI with onset reported [less than or equal to]5 y before the 2013-2015 follow-up.
3.7 Self-Assembly of Pingyangmycin into Functionalized HPEE. To verify the nanocarrier platform based on HPEE functionalized derivants for individualized antitumor drug delivery, we used pingyangmycin as a model drug.
As shown in Scheme 1, ion-transfer polymerization was observed during HPEE terminal functionalization.
Although good biocompatibility of hyperbranched polymers has been reported [27], the potential cytotoxicity of functionalized HPEE has not been documented.
As shown in Scheme 2, taking into account the amino-bonding surface of pingyangmycin, electrostatic interactions would theoretically be formed between the positive-charged protonated amines of pingyangmycin and the surface carboxyl groups on the oxidized HPEE [35]; therefore, a self-assembled micelle could potentially be constructed in water.
After the physical-chemical interrelationship between surface terminal and charge loading of HPEE was revealed, pingyangmycin, a potent antitumor drug, was used as a model drug to assess the HPEE-dependent nanocarrier system.
HPEE: Hyper-branched poly(ether-ester) HPE: Hyper-branched poly(ether) PEE: Poly(ether-ester) PE: Poly(ether) HBP: Hyper-branched polymers PYM: Pingyangmycin.