HPFHHereditary Persistence of Fetal Hemoglobin
HPFHHeterocellular Persistence of Fetal Hemoglobin
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Individuals with HPFH demonstrate that preventing or reversing the switch from fetal to adult hemoglobin would provide efficacious therapy for thalassemia and various other hemoglobinopathies.
Populations with HPFH exhibit elevated HbF expression, which persists throughout adulthood, and do not manifest the clinical pathologies of SCD despite having the beta-chain mutation.
anemia SS 65 FS FS Severe (by one year) * SC 25 FSC FSC Mild-Moderate (by one years) S 8 FSA or FS FSA Mild-Moderate [beta]-plus (by two thalassemia years) S 2 FS FS Severe (by one [beta]-zero year) thalassemia S HPFH 1 FS FS None Hematologic studies by two years Disorder MCV Hemoglobin Hemoglobin [A.