HPMCPHydroxy Propyl Methyl Cellulose Phthalate
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Microspheres were prepared by spraying solutions obtained by dissolving T and MC (T-MC) or HPMCP (T-HPMCP) polymers in a methanol and dichloromethane mixture (50-50 v/v); concentrations of total solid in solutions were 2% and 5% (wt/v) for T-MC and T-HPMCP, respectively.
Thymol microspheres were produced by spray-drying technique using MC and HPMCP as polymers, spray-drying appears to be a suitable method for the preparation of T loaded microspheres; yield of production depends on polymer used and it decreases significantly when MC is used as well as the encapsulation efficiency (p < 0.0001) (Table 1).
This behaviour can be due to the slow evaporation of T from the polymer matrix and HPMCP is more able to retain T in the microspheres than MC.