4 mg/d) in the HPOO group thusly no subgroup analysis could be performed.
The included trials can only hint towards the role of HPOO with respect to the effects of the Mediterranean diet.
As HPOO has small effects on systolic blood pressure it could be advised as a dietary fat in the primary prevention of CVDs.
To achieve the same high level of daily oil consumption (respectively phenol intake) like in the trials HPOO has to be used as the primary source of fat.
As the results indicate the effectiveness of HPOO this should be further evaluated in better powered trials and in intervention with longer observation periods.