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The HPTN 071 (PopART) study involved more than one million people living in 21 communities in Zambia and South Africa, making it the largest HIV prevention trial to date.
"Young African women share a disproportionate burden and are especially vulnerable to this epidemic."A related study, HPTN 083, is testing the safety and efficacy of injectable CAB for HIV prevention in 4,500 men who have sex with men and transgender women who have sex with men.
Health diplomacy and the adaptation of global health interventions to local needs in sub-Saharan Africa and Thailand: evaluating findings from Project Accept (HPTN 043).
Little is known about the impact of combination of HIV prevention interventions for men who have sex with men (MSM) HPTN 052 randomised controlled trial, ART used in combination with condoms and counselling reduced HIV transmission by 96.4%.
A recent study known as ADAPT HPTN 067, conducted in Cape Town, SA, randomised 179 heterosexual women into three arms of self-administered daily, event-driven and intermittent TDF/FTC PrEP over a 24-week period.
Recent results of the START, TEMPRANO and HPTN 052 studies, as well as various pre exposure prophylaxis (PrEP) studies have led to new approaches for treatment and prevention.
(2.) Myron Cohen, MD, an HIV researcher at the University of North Carolina, Chapel Hill and lead investigator of HPTN 052, headed a study that proved treating HIV also prevents transmission of HIV.
The HPTN 052  and PARTNER  studies show that HIV-positive people with suppressed viral loads and who are receiving treatment will not transmit the virus to HIV-negative sexual partners.
With the striking success of the HPTN 052 trial, early initiation of antiretroviral (ARV) treatment seems poised to join condoms, partner reduction, clean needles and voluntary medical male circumcision in the toolbox of comprehensive combination prevention.
Community-based intervention to increase HIV testing and case detection in people aged 16-32 years in Tanzania, Zimbabwe, and Thailand (NIMH Project Accept, HPTN 043): a randomised study.
Jackson et al., "One year of counseling supported buprenorphine-naloxone treatment for HIV prevention in opiate dependent injecting drug users showed efficacy in reducing opiate use and injection frequency: HPTN 058 in Thailand and China.
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