The main study variables were anti-HPV 6, 11, 16, 18 serum antibody status (outcome variable) and HPV 6, 11, 16, 18 DNA status in cervix and anus (independent variables).
The prevalence of antibodies was highest for HPV 6 (27.4%), followed by HPV 16 (22.1%), HPV 11 (16.4%) and HPV 18 (15.6%), with 46.9% seroprevalence for any of these HPV.
The association between any cervical HPV 6, 11, 16, 18 DNA and any HPV serology showed a trend toward statistical significance (p=0.07).
In the 47 cases where HPV 6, 11, 16, and 18 were detected by sequencing, type-specific, real-time PCR confirmed the presence of the expected HPV type.
L1 sequencing of laryngeal RPR biopsies demonstrated only 2 HPV types: HPV 6 and HPV 11.
Type-specific, real-time PCR confirmed the presence of the expected HPV type in all 47 anal and laryngeal specimens with HPV 6, 11, 16, and/or 18 detected by sequencing.
The study found that quadrivalent HPV vaccine prevented infection with HPV 6
, 11, 16, and 18 and the development of related external genital lesions in young men aged 16-26 years.
Of those 30 types, these vaccines take care of four: HPV 6
, 11, 16, and 18.
For a person exposed to a partner who has a low-risk genital wart-causing strain of HPV such as HPV 6
or 11, it usually takes about six weeks to three months for genital warts to appear.
Regrettably, fewer than 40% of the eligible female population of the United States has received one or more injections of either the bivalent (HPV 16, 18) (Cervarix) or quadrivalent (HPV 6
, 11, 16, 18) (Gardasil) vaccine--with the vaccination rate varying considerably by geographic location and socioeconomic status.
The FDA-approved HPV test identifies a pool of high-risk HPV types and is not restricted to the 4 HPV types in the vaccine (HPV 6
, 11, 16, and 18).