HPV-18Human Papilloma Virus Type 18 Transforming Gene
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Detection rate for patients that reported tobacco, alcohol and illicit drugs consumption was 85.4% (35/41) and 22.8% (8/35) of these showed multiple infections by HPV-6/11 and HPV-18. There was no statistical difference between these patients and those that did not consume any abusive substances (p = 0.550).
In addition to HPV-16, the most common genotypes were HPV-31 (15.62%), HPV6 (14.58%), HPV-18 (10.41%), HPV-45 and HPV-11 (9.37%), HPV-33 (7.29%) and HPV-35, -52, -56 (5.21%).
The HPV genotyping real-time PCR kit (Shanghai ZJ Bio-Tech Co., Ltd., Shanghai, China) was used to detect HPV genotypes, including HPV-16, HPV-18, HPV-31, HPV-33, HPV-35, HPV-39, HPV-45, HPV-51, HPV-52, HPV-56, HPV-58, HPV-59, and HPV-68.
The most recent American Society of Colposcopy and Cervical Pathology management guidelines (2012) (10) suggested an earlier colposcopic examination for the small population of women with negative Pap test and positive HPV-16 or HPV-18 results.
Out of the 14 HPV DNA positive cases, 13 (92.9%) were infected with HPV-18 genotype, and 1 (7.1%) was infected with HPV-31 (Figure 2).
These are; HPV-6, HPV-11, HPV-16, HPV-18, HPV31, HPV-33, HPV-45, HPV-52 and HPV-58.
Among the numerous members of the HPV family, 15 HPV genotypes (types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, 73, and 82) are associated with a high risk for cervical cancer; in particular, HPV-16 and HPV-18 account for 70% of all cervical cancer cases, and HPV-16 is the most common form of HPV [6, 7].
It was found after application and analysis of (ISH) for detection of HPV-18 DNA in the tissues obtained from patients with Thyroid cancer as well as benign Thyroidneoplasia that seventeen (D'Souza, 2013) out of thirty patients with carcinoma of thyroid showed positive In Situ Hybrization reaction where it constituted 56.7% of the total prostatic cancer cases of this study (table 1 and figure 1).
HPV also causes throat cancers, most cases being caused by HPV-16 and HPV-18, and this cancer is the fastest rising of any cancer - at 15% a year.
(10) Among girls age 14 to 19, infections with HPV-16 and HPV-18 have declined 50% (from 7.2% to 3.6%).
(25), em 2007, que comparou seis estudos de fase II e III, constatou que a vacina profilatica obteve eficacia de 100% contra neoplasia cervical intraepitelial ou adenocarcinoma in situ, causadas pelo HPV-16 e HPV-18 (9,25).