HRD1Hypoxia Responsive Domain-1
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Taken together, the impairment of members of the UPS different from the 26S proteasome itself, such as Parkin, HRD1, and UCHL1, may affect APP processing and A[beta] production.
showed that HRD1 protein was insolubilized by oxidative stress but not by other AD-related molecules and stressors, such as amyloid-[beta], tau, and ER stress.
Quite recently, HRD1 ubiquitin ligase, previously reported to favor APP degradation [59], was also identified as a negative regulator of tau phosphorylation in AD [86].