HRIGHuman Rabies Immune Globulin
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HRIG is a component of rabies post-exposure prophylaxis (PEP).
of dose schedule of ARV: [chi square] =75.97p=.0000000 * Awareness of ID Vaccine schedule: [chi square] =2.29p=0.130 Awareness of ID Vaccine site: [chi square] =4.67p=0.030 * Awareness of ID Vaccine dose: [chi square] =4.67p=0.030 * PEP in immunised: [chi square] =1.60p=0.26 Indication of HRIG: [chi square] =1.7p=0.19 Site/mode of adm.
After initial wound management, rabies post-exposure prophylaxis, including PVRV and HRIG (20 IU/Kg) was administrated.
As an alternative to HRIG, equine immune globulin derived from horse serum is used in many parts of the world, but it is also scarce, expensive and can carry significant side effects.
On March 14, after notification of positive rabies serology results, the girl received 1 dose of rabies vaccine and 1,500 IU of HRIG. Additional doses of vaccine were not administered because of concern over possible adverse effects from potentiating the immune response.
However, hRIG, which is derived from human blood, is an expensive material and is often not available in developing countries.
Of 1,248 PEP cases reported from 1998 to 2000, administration of PEP biologics was recorded as complete and appropriate (e.g., HRIG was given if indicated and the person completed all 5 vaccinations) in 1,035 (83%) cases.
After counseling, respondents pursued or declined PEP, a regimen normally composed of 1 dose of human rabies immune globulin (HRIG) infiltrated in the wound (when applicable) or administered intramuscularly on day 0 (day of initiation) and five injections of rabies vaccine administered intramuscularly on days 0, 3, 7, 14, and 28 (in previously unvaccinated persons).
Standard human rabies immune globulin (HRIG) diluted to contain 2 IU/mL antibodies was used as a positive serum control for all tests.
* Where available (including the United Stares), Human Rabies Immune Globulin (HRIG) is preferred and is administered in a dose of 20 IU/kg.